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Feasibility study of exploring a T 1 ‐weighted dynamic contrast‐enhanced MR approach for brain perfusion imaging
Author(s) -
Zhang Yudong,
Wang Jing,
Wang Xiaoying,
Zhang Jue,
Fang Jing,
Jiang Xuexiang
Publication year - 2012
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.23570
Subject(s) - nuclear medicine , cerebral blood flow , perfusion , perfusion scanning , cerebral blood volume , mean transit time , medicine , dynamic contrast , limits of agreement , arterial spin labeling , white matter , cerebral perfusion pressure , magnetic resonance imaging , nuclear magnetic resonance , physics , cardiology , radiology
Purpose: To investigate the feasibility of T 1 ‐weighted dynamic contrast‐enhanced (DCE) MRI for the measurement of brain perfusion. Materials and Methods: Dynamic imaging was performed on a 3.0 Tesla (T) MR scanner by using a rapid spoiled‐GRE protocol. T 1 measurement with driven equilibrium single pulse observation of T 1 (DESPOT1) was used to convert the MR signal to tracer concentration. Cerebral perfusion maps were obtained by using an improved gamma‐variate model in 10 subjects and compared with those with arterial spin label (ASL) approach. Results: The cerebral blood volume (CBV) values were calculated as 4.74 ± 1.09 and 2.29 ± 0.58 mL/100 g in gray matter (GM) and whiter matter (WM), respectively. Mean transit time (MTT) values were 6.15 ± 0.59 s in GM and 6.96 ± 0.79 s in WM. The DCE values for GM/WM cerebral blood flow (CBF) were measured as 53.41 ± 9.23 / 25.78 ± 8.91 mL/100 g/min, versus ASL values of 49.05 ± 10.81 / 23.00 ± 5.89 mL/100 g/min for GW/WM. Bland‐Altman plot revealed a small difference of CBF between two approaches (mean bias = 3.83 mL/100 g/min, SD = 11.29). There were 6 pairs of samples (5%, 6/120) beyond the 95% limits of agreement. The correlation plots showed that the slop of Y (CBF_ DCE ) versus X intercept (CBF_ ASL ) is 0.95 with the intercept of 4.53 mL/100 g/min ( r = 0.74; P < 0.05). Conclusion: It is feasible to evaluate the cerebral perfusion by using T 1 ‐weighted DCE‐MRI with the improved kinetic model. J. Magn. Reson. Imaging 2012;35:1322–1331. © 2012 Wiley Periodicals, Inc.