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1 H‐magnetic resonance spectroscopy of the breast at 3.0‐T: Comparison of results obtained before and after administration of gadolinium‐based contrast agent
Author(s) -
Kawai Hisashi,
Naganawa Shinji,
Satake Hiroko,
Ishigaki Satoko,
Sakurai Yasuo,
Mori Minako,
Maruyama Katsuya
Publication year - 2012
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.22893
Subject(s) - gadolinium , medicine , nuclear medicine , magnetic resonance imaging , voxel , breast cancer , in vivo magnetic resonance spectroscopy , choline , radiology , nuclear magnetic resonance , cancer , chemistry , physics , organic chemistry
Purpose: To assess the effects of gadolinium‐based contrast agent (GBCA) on 1 H‐magnetic resonance spectroscopy (MRS) of the breast at 3.0‐T. Materials and Methods: Patients ( n = 98) with breast cancer (98 lesions) underwent MRS (point‐resolved spectroscopy sequence [PRESS]; TR/TE, 2000/100 msec; voxel size, 15 × 15 × 15 mm) before the administration of GBCA. In 52 of those patients, MRS was also performed after the administration of GBCA. The voxel‐of‐interest (VOI) was placed by referring to the noncontrast‐enhanced MRI (diffusion‐weighted images combined with fat‐suppressed T2‐weighted images). We reviewed and graded the appropriateness of VOI location compared to the correlating enhancement lesions. Integral values of the choline peak at a frequency of 3.2 ppm on MRS were compared before and after the administration of GBCA. Results: The VOI was placed correctly in 64 lesions (65%), although the VOI was placed outside the targeted lesion in 34 lesions (35%). The integral value of the choline peak on MRS decreased significantly after the administration of GBCA ( P < 0.001). Conclusion: Accumulation of GBCA in breast cancer could affect the choline peak on MRS. MRS of breast cancer at 3.0‐T can be recommended to be acquired before contrast‐enhanced study; however, some problems remain in VOI placement with reference to the noncontrast‐enhanced study. J. Magn. Reson. Imaging 2012;35:717‐722. © 2011 Wiley Periodicals, Inc.