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Perfusion parameters analysis of the vertebral bone marrow in patients with Ph 1− chronic myeloproliferative neoplasms (Ph neg MPN): A dynamic contrast‐enhanced MRI (DCE‐MRI) study
Author(s) -
Courcoutsakis Nikos,
Spanoudaki Athina,
Maris Thomas G.,
Astrinakis Emmanuel,
Spanoudakis Emmanuel,
Tsatalas Constantinos,
Prassopoulos Panos
Publication year - 2012
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.22870
Subject(s) - myelofibrosis , medicine , perfusion , polycythemia vera , bone marrow , magnetic resonance imaging , nuclear medicine , vascularity , group b , gastroenterology , radiology
Purpose: To evaluate perfusion parameters of the vertebral bone marrow in patients with Philadelphia negative chronic myeloproliferative neoplasms (Ph neg MPN) using dynamic contrast‐enhanced MRI (DCE‐MRI). Materials and Methods: The study enrolled 24 patients with Ph neg MPN: 12 patients with myelofibrosis (Group A), 6 with essential thrombocythemia (ET), and 6 with polycythemia vera (PV) (Group B) who underwent DCE‐MRI of the lumbosacral spine. Twelve normal individuals served as control group (Group C). Wash‐in (WIN), wash‐out (WOUT), maximum contrast‐enhancement (CE max), time‐to‐peak (TTPK), time‐to‐maximum slope (TMSP), and the WIN/TMSP ratio (WTSP) were calculated. Results: WIN, CE max , and WTSP parameters were higher in Group A than in Group C ( P < 0.05). These parameters were significant ( P < 0.0001) in discriminating patients with myelofibrosis from normal individuals with sensitivities 74.14%, 87.93%, 74.14%, and specificities 91.07%, 83.93%, 91.07%, respectively. WIN, WOUT, CE max , and WTSP parameters were higher in Group A than in Group B ( P < 0.05). Group B exhibited no differences in perfusion parameters as compared with Group C with the exception of WOUT. Conclusion: Patients with myelofibrosis exhibited increased perfusion parameters in vertebral bone marrow, which could be consisted with increased vascularity, probably related to neoangiogenesis as opposed to ET or PV patients showing no increased perfusion. DCE‐MRI may be of value in discriminating subgroups of Ph neg MPN patients and in indicating those progressing to myelofibrosis. J. Magn. Reson. Imaging 2012;35:696‐702. © 2011 Wiley Periodicals, Inc.