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Early (72‐Hour) detection of radiotherapy‐induced changes in an experimental tumor model using diffusion‐weighted imaging, diffusion tensor imaging, and Q‐space imaging parameters: A comparative study
Author(s) -
Peeters Frank,
Rommel Denis,
AbarcaQuis Jorge,
Grégoire Vincent,
Duprez Thierry
Publication year - 2012
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.22836
Subject(s) - diffusion mri , kurtosis , nuclear magnetic resonance , effective diffusion coefficient , nuclear medicine , magnetic resonance imaging , fractional anisotropy , diffusion , flip angle , physics , materials science , mathematics , medicine , radiology , statistics , thermodynamics
Abstract Purpose: To assess and compare the potential of various diffusion‐related magnetic resonance imaging (MRI) parameters to detect early radiotherapy (RT)‐induced changes in tumors. Materials and Methods: Nineteen tumors in a rat model were imaged on a clinical 3T system before and 72 hours after a single RT session. Diffusion imaging was performed using an echo planar sequence containing 16 b‐factors and six gradient directions. This allowed us to perform a tensor analysis of mono‐ and biexponential decays and a q‐space analysis. Parametric maps (both trace and fractional anisotropy) were reconstructed for: 2‐point apparent diffusion coefficient (ADC), 16‐point ADC, biexponential amplitudes and ADCs, and height, width, and kurtosis of the probability density function (PDF). A texture analysis yielded quantities such as average and contrast. The sensitivity of diffusion‐related parameters was quantified in terms of the mean relative difference (when comparing pre‐ and post‐RT status). Results: Traces and anisotropies display differences in response to RT. Average traces are most sensitive for ADCs and kurtosis. Average anisotropies are all very sensitive except the slow biexponential component. The best contrast (traces) was found for the ADCs and the width of the PDF. Conclusion: ADC performed well, but high b‐values analysis added extra sensitive parameters for monitoring early RT‐induced changes. J. Magn. Reson. Imaging 2012;409‐417. © 2011 Wiley Periodicals, Inc.