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Age‐related cerebral perfusion changes in the parietal and temporal lobes measured by pulsed arterial spin labeling
Author(s) -
Preibisch Christine,
Sorg Christian,
Förschler Annette,
Grimmer Timo,
Sax Iris,
Wohlschläger Afra M.,
Perneczky Robert,
Förstl Hans,
Kurz Alexander,
Zimmer Claus,
Alexopoulos Panagiotis
Publication year - 2011
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.22788
Subject(s) - arterial spin labeling , reproducibility , cerebral blood flow , cuneus , perfusion , parietal lobe , medicine , neuroscience , cardiology , chemistry , psychology , radiology , precuneus , functional magnetic resonance imaging , chromatography
Purpose: To investigate age‐related regional perfusion changes focused on the medial temporal lobes and related parietal areas using a pulsed arterial spin labeling technique. Materials and Methods: Resting cerebral blood flow (CBF) maps were obtained from 44 healthy volunteers (18 male, 26 female; age range, 19 to 79 years) using a pulsed arterial spin labeling (PASL) MRI technique at 3 Tesla focused on the parietal and temporal lobes. Repeated measurements were performed in 20 subjects to assure the reliability and reproducibility of the applied PASL technique. Results: Focal age‐related CBF decreases were detected in the parietal cortex, cuneus and caudate, whereas increases were seen in the lateral and medial temporal lobe such as hippocampus, the calcarine gyrus and the thalamus. Moreover, repeated measurements demonstrated a high reliability and reproducibility of the applied PASL technique. Conclusion: Data provide evidence for regionally dissociated patterns of perfusion increases and decreases during ageing in the temporal and parietal lobes. J. Magn. Reson. Imaging 2011;. © 2011 Wiley Periodicals, Inc.