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DCE‐MRI model selection for investigating disruption of microvascular function in livers with metastatic disease
Author(s) -
Banerji Anita,
Naish Josephine H.,
Watson Yvonne,
Jayson Gordon C.,
Buonaccorsi Giovanni A.,
Parker Geoffrey J.M.
Publication year - 2012
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.22692
Subject(s) - akaike information criterion , voxel , liver tumor , hepatic tumor , medicine , pathology , nuclear medicine , radiology , hepatocellular carcinoma , mathematics , statistics
Purpose: To evaluate the Akaike information criterion (AIC) model selection technique as a method for detecting differences in microvascular characteristics between tumorous and non‐tumor liver tissue. Materials and Methods: The AIC was applied to six patient datasets with liver metastases to determine, on a per voxel basis, which of two physiologically plausible candidate models gave a more appropriate description of the data. The dual‐input single‐compartment Materne model, extended to incorporate a novel portal input function estimation method, was chosen to represent liver tissue and the single‐input dual‐compartment extended Kety model was used for tumor. Results: Median AIC probabilities when comparing tumor versus liver and tumor versus tumor‐margins were significantly different ( P ≤ 0.01) in five of the six patient datasets. Comparisons between tumor margins and liver regions were significantly different in four datasets. Median AIC probabilities selected for the extended Kety model in all tumor regions, with the Materne model being progressively more probable through tumor margins into liver. Conclusion: We present a viable method for assessing the spatially varying microvascular characteristics of tumor‐bearing livers, with possible applications in lesion detection, assessment of tumor invasion, and measurement of drug efficacy. J. Magn. Reson. Imaging 2012;35:196‐203. © 2011 Wiley Periodicals, Inc.