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31 P MR spectroscopic imaging detects regenerative changes in human liver stimulated by portal vein embolization
Author(s) -
Qi Jing,
ShuklaDave Amita,
Fong Yuman,
Gönen Mithat,
Schwartz Lawrence H.,
Jarnagin William M.,
Koutcher Jason A.,
Zakian Kristen L.
Publication year - 2011
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.22616
Subject(s) - portal vein embolization , portal vein , medicine , radiology , nuclear medicine , magnetic resonance imaging , human liver , nuclear magnetic resonance , hepatectomy , physics , surgery , resection , enzyme
Purpose: First, to evaluate hepatocyte phospholipid metabolism and energetics during liver regeneration stimulated by portal vein embolization (PVE) using proton‐decoupled 31 P MR spectroscopic imaging ( 31 P‐MRSI). Second, to compare the biophysiologic differences between hepatic regeneration stimulated by PVE and by partial hepatectomy (PH). Materials and Methods: Subjects included six patients with hepatic metastases from colorectal cancer who were scheduled to undergo right PVE before definitive resection of right‐sided tumor. 31 P‐MRSI was performed on the left liver lobe before PVE and 48 h following PVE. Normalized quantities of phosphorus‐containing hepatic metabolites were analyzed from both visits. In addition, MRSI data at 48 h following partial hepatectomy were compared with the data from the PVE patients. Results: At 48 h after PVE, the ratio of phosphomonoesters to phosphodiesters in the nonembolized lobe was significantly elevated. No significant changes were found in nucleoside triphosphates (NTP) and Pi values. The phosphomonoester (PME) to phosphodiester (PDE) ratio in regenerating liver 48 h after partial hepatectomy was significantly greater than PME/PDE 48 h after PVE. Conclusion: 31 P‐MRSI is a valid technique to noninvasively evaluate cell membrane metabolism following PVE. The different degree of biochemical change between partial hepatectomy and PVE indicates that hepatic growth following these two procedures does not follow the same course. J. Magn. Reson. Imaging 2011;. © 2011 Wiley‐Liss, Inc.