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Measurement of aortic arch pulse wave velocity in cardiovascular MR: Comparison of transit time estimators and description of a new approach
Author(s) -
Dogui Anas,
Redheuil Alban,
Lefort Muriel,
DeCesare Alain,
Kachenoura Nadjia,
Herment Alain,
Mousseaux Elie
Publication year - 2011
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.22570
Subject(s) - pulse wave velocity , aortic arch , medicine , ascending aorta , pulse wave analysis , cardiology , aorta , nuclear medicine , mathematics , blood pressure
Purpose: To investigate the efficiency of a new method (TT‐Upslope) for transit time (Δt) estimation from cardiovascular MR (CMR) velocity curves. Materials and Methods: Fifty healthy volunteers (40 ± 15 years) underwent applanation tonometry to estimate carotid–femoral pulse wave velocity (cf‐PWV) and carotid pressure measurements, and CMR to estimate aortic arch‐PWV and ascending aorta distensibility (AAD). The Δt was calculated with TT‐Upslope by minimizing the area delimited by two sigmoid curves fitted to the systolic upslope of the ascending (AAC) and descending (DAC) aorta velocity curves, and compared with previously described methods: TT‐Point using the half maximum of AAC and DAC, TT‐Foot using AAC and DAC feet, and TT‐Wave by minimizing the area between AAC and DAC curves using cross correlation. Results: All the Δt methods provided a high reproducibility of arch‐PWV. However, TT‐Upslope and TT‐Wave resulted in better correlations with aging (r = 0.83/r = 0.83 versus r = 0.47/r = 0.72), cf‐PWV (r = 0.69/r = 0.70 versus r = 0.34/r = 0.59), and AAD (r = 0.81/r = 0.71 versus r = 0.61/r = 0.60). Furthermore, TT‐Upslope resulted in stronger relationship between arch‐PWV and AAD according to a theoretical model and provided better characterization of older subjects compared with TT‐Wave. Conclusion: Arch‐PWV estimated with CMR using the TT‐Upslope method was found to be reproducible and accurate, providing strong correlations with age and aortic stiffness indices. J. Magn. Reson. Imaging 2011;33:1321–1329. © 2011 Wiley‐Liss, Inc.