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Measurement and comparison of T1 relaxation times in native and transplanted kidney cortex and medulla
Author(s) -
Huang Yin,
Sadowski Elizabeth A.,
Artz Nathan S.,
Seo Songwon,
Djamali Arjang,
Grist Thomas M.,
Fain Sean B.
Publication year - 2011
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.22543
Subject(s) - medulla , medullary cavity , renal medulla , cortex (anatomy) , renal function , kidney , medicine , magnetic resonance imaging , urology , reproducibility , transplanted kidney , renal cortex , transplantation , pathology , kidney transplantation , anatomy , chemistry , radiology , biology , neuroscience , chromatography
Abstract Purpose: To measure and compare cortical and medullary T1 values in native and transplanted kidneys with a wide range of function as measured by estimated glomerular filtration rate (eGFR). Materials and Methods: A total of 27 subjects (12 native and 15 transplants) were studied. Two magnetic resonance imaging (MRI) exams of T1 measurement were performed on separate days for reproducibility study. Group‐wise comparisons of renal T1 on day 1 were performed between subjects with native and transplanted kidneys and also between subjects based on an eGFR threshold of 60 mL/min/1.73m 2 . Results: Transplanted kidneys had higher cortical renal T1 (1183 ± 136 msec) than native kidneys (1057 ± 94 msec) with similar results in the medulla. Subjects with an eGFR < 60 mL/min/1.73m 2 had higher renal T1 than subjects with an eGFR > 60 mL/min/1.73m 2 (cortical T1: P < 0.0001; medullary T1: P = 0.008). Renal T1 was highly reproducible for both native and transplant groups (with percent differences less than 10%). Conclusion: There are differences in cortical and medullary T1 between native and transplanted kidneys at different levels of function. J. Magn. Reson. Imaging 2011;33:1241–1247. © 2011 Wiley‐Liss, Inc.