Premium
Posterior hypoperfusion in parkinson's disease With and without dementia measured with arterial spin labeling MRI
Author(s) -
Kamagata Koji,
Motoi Yumiko,
Hori Masaaki,
Suzuki Michimasa,
Nakanishi Atsushi,
Shimoji Keigo,
Kyougoku Shinsuke,
Kuwatsuru Ryohei,
Sasai Keisuke,
Abe Osamu,
Mizuno Yoshikuni,
Aoki Shigeki,
Hattori Nobutaka
Publication year - 2011
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.22515
Subject(s) - cerebral blood flow , perfusion , medicine , arterial spin labeling , dementia , post hoc analysis , bonferroni correction , parkinson's disease , blood flow , cerebral perfusion pressure , perfusion scanning , cortex (anatomy) , cardiology , magnetic resonance imaging , nuclear medicine , radiology , disease , neuroscience , psychology , statistics , mathematics
Abstract Purpose: To determine whether quantitative arterial spin labeling (ASL) can be used to evaluate regional cerebral blood flow in Parkinson's disease with dementia (PDD) and without dementia (PD). Materials and Methods: Thirty‐five PD patients, 11 PDD patients, and 35 normal controls were scanned by using a quantitative ASL method with a 3 Tesla MRI unit. Regional cerebral blood flow was compared in the posterior cortex using region‐of‐interest analysis. Results: PD and PDD patients showed lower regional cerebral blood flow in the posterior cortex than normal controls ( P = 0.002 and P = 0.001, respectively, analysis of variance with a Bonferroni post hoc test). Conclusion: This is the first study to detect hypoperfusion in the posterior cortex in PD and PDD patients using ASL perfusion MRI. Because ASL perfusion MRI is completely noninvasive and can, therefore, safely be used for repeated assessments, this method can be used to monitor treatment effects or disease progression in PD. J. Magn. Reson. Imaging 2011;33:803–807. © 2011 Wiley‐Liss, Inc.