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Dynamic nuclear polarization system output volume reduction using inert fluids
Author(s) -
Peterson Eric T.,
Gordon Jeremy W.,
Erickson Matthew G.,
Fain Sean B.,
Rowland Ian J.
Publication year - 2011
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.22498
Subject(s) - polarizer , inert , polarization (electrochemistry) , aqueous solution , dissolution , materials science , volume (thermodynamics) , inert gas , chemistry , birefringence , organic chemistry , optics , composite material , thermodynamics , physics
Purpose: To present a method for significantly increasing the concentration of a hyperpolarized compound produced by a commercial dynamic nuclear polarization (DNP) polarizer, enabling the polarization process to be more suitable for preclinical applications. Materials and Methods: Using a HyperSense DNP polarizer, we investigated the combined use of perfluorocarbon and water to warm and dissolve the hyperpolarized material from the polarization temperature of 1.4K to produce material at temperatures suitable for injection. Results: By replacing 75% of the water in the dissolution volume with a chemically and biologically inert liquid that is immiscible with water, the injection volume can be reduced 4‐fold. Rapid separation of the water and perfluorocarbon mixture enables the aqueous layer containing polarized material to be easily and rapidly collected. Conclusion: The approach provides a significantly increased concentration of compound in a volume for injection that is more appropriate for small animal studies. This is demonstrated for 13 C‐labeled pyruvic acid and 13 C‐labeled succinate, but may be applied to the majority of nuclei and compounds hyperpolarized by the DNP method. J. Magn. Reson. Imaging 2011;33:1003–1008. © 2011 Wiley‐Liss, Inc.