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Impact of nonrigid motion correction technique on pixel‐wise pharmacokinetic analysis of free‐breathing pulmonary dynamic contrast‐enhanced MR imaging
Author(s) -
Tokuda Junichi,
Mamata Hatsuho,
Gill Ritu R.,
Hata Nobuhiko,
Kikinis Ron,
Padera Robert F.,
Lenkinski Robert E.,
Sugarbaker David J.,
Hatabu Hiroto
Publication year - 2011
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.22490
Subject(s) - contrast (vision) , dynamic contrast , breathing , dynamic contrast enhanced mri , motion (physics) , medicine , nuclear medicine , computer science , radiology , computer vision , magnetic resonance imaging , biomedical engineering , anatomy
Purpose: To investigates the impact of nonrigid motion correction on pixel‐wise pharmacokinetic analysis of free‐breathing DCE‐MRI in patients with solitary pulmonary nodules (SPNs). Misalignment of focal lesions due to respiratory motion in free‐breathing dynamic contrast‐enhanced MRI (DCE‐MRI) precludes obtaining reliable time–intensity curves, which are crucial for pharmacokinetic analysis for tissue characterization. Materials and Methods: Single‐slice 2D DCE‐MRI was obtained in 15 patients. Misalignments of SPNs were corrected using nonrigid B‐spline image registration. Pixel‐wise pharmacokinetic parameters K trans , v e , and k ep were estimated from both original and motion‐corrected DCE‐MRI by fitting the two‐compartment pharmacokinetic model to the time–intensity curve obtained in each pixel. The “goodness‐of‐fit” was tested with χ 2 ‐test in pixel‐by‐pixel basis to evaluate the reliability of the parameters. The percentages of reliable pixels within the SPNs were compared between the original and motion‐corrected DCE‐MRI. In addition, the parameters obtained from benign and malignant SPNs were compared. Results: The percentage of reliable pixels in the motion‐corrected DCE‐MRI was significantly larger than the original DCE‐MRI ( P = 4 × 10 −7 ). Both K trans and k ep derived from the motion‐corrected DCE‐MRI showed significant differences between benign and malignant SPNs ( P = 0.024, 0.015). Conclusion: The study demonstrated the impact of nonrigid motion correction technique on pixel‐wise pharmacokinetic analysis of free‐breathing DCE‐MRI in SPNs. J. Magn. Reson. Imaging 2011;33:968–973. © 2011 Wiley‐Liss, Inc.