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Amide proton transfer MR imaging of prostate cancer: A preliminary study
Author(s) -
Jia Guang,
Abaza Ronney,
Williams JoAnna D.,
Zynger Debra L.,
Zhou Jinyuan,
Shah Zarine K.,
Patel Mitva,
Sammet Steffen,
Wei Lai,
Bahnson Robert R.,
Knopp Michael V.
Publication year - 2011
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.22480
Subject(s) - prostate cancer , prostatectomy , magnetization transfer , medicine , prostate , nuclear medicine , cancer , magnetic resonance imaging , biopsy , radiology , pathology
Purpose: To evaluate the capability of amide proton transfer (APT) MR imaging for detection of prostate cancer that typically shows a higher tumor cell proliferation rate and cellular density leading to an MRI‐detectable overall elevated mobile protein level in higher grade tumors. Materials and Methods: Twelve patients with biopsy‐proven prostate cancer were imaged on a 3 Tesla MR imaging system before prostatectomy. APT‐MR images were acquired by means of a single‐slice single‐shot turbo spin echo sequence with a saturation prepulse preparation using 33 different frequency offsets (−8 to 8 ppm, interval 0.5 ppm). For quantification we used the APT ratio (APTR) based on the asymmetry of the magnetization transfer ratio at 3.5 ppm in respect to the water signal. Tumor and peripheral zone benign regions of interest (ROIs) were delineated based on whole mount pathology slides after prostatectomy. Results: APTR in prostate cancer ROIs was 5.8% ± 3.2%, significantly higher than that in the peripheral zone benign regions (0.3% ± 3.2%, P = 0.002). Conclusion: APT‐MR imaging is feasible in prostate cancer detection and has the potential to discriminate between cancer and noncancer tissues. J. Magn. Reson. Imaging 2011;33:647–654. © 2011 Wiley‐Liss, Inc.