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Early versus late GD‐DTPA MRI enhancement in experimental glioblastomas
Author(s) -
Farace Paolo,
Tambalo Stefano,
Fiorini Silvia,
Merigo Flavia,
Daducci Alessandro,
Nicolato Elena,
Conti Giamaica,
Degrassi Anna,
Sbarbati Andrea,
Marzola Pasquina
Publication year - 2011
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.22472
Subject(s) - medicine , histology , glioblastoma , nuclear medicine , edema , bolus (digestion) , magnetic resonance imaging , radiology , pathology , anatomy , surgery , cancer research
Abstract Purpose: To compare early versus late enhancement in two glioblastoma models characterized by different infiltrative/edematous patterns. Materials and Methods: Three weeks after inoculation into nude mice of U87MG and U251 cells, T1‐weighted images were acquired early (10.5 min), intermediate (21 min) and late (30.5 min) after a bolus injection of Gd‐DTPA at 300 μ mol/kg dosage. EARLY TH and LATE TH were the corresponding volumes with an enhancement higher than a threshold TH, defined by the mean (μ) and standard deviation (σ) on a contralateral healthy area. ADD TH was the enhancing volume found in LATE TH but not in EARLY TH . T2 imaging of both tumors was performed, and T2 mapping of U251. Results: In all tumors, LATE TH was significantly higher than EARLY TH for TH ranging from μ+σ to μ+5σ. The ADD TH /EARLY TH ratio was not significantly different when U251 and U87MG tumors were compared. In the U87MG tumors, some enhancement was observed outside the regularly demarcated T2‐hyperintense area. In the U251 tumors, irregularly T2 demarcated, a large portion of ADD μ+3σ had normal T2 values. At histology, U251 showed a higher infiltrative pattern than U87MG. Conclusion: In these models, the increase over time in the enhancing volume did not depend on the different infiltrative/edematous patterns and was not closely related with edema. J. Magn. Reson. Imaging 2011;33:550–556. © 2011 Wiley‐Liss, Inc.