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Dynamic contrast‐enhanced MRI of primary rectal cancer: Quantitative correlation with positron emission tomography/computed tomography
Author(s) -
Gu Jing,
Khong PekLan,
Wang Silun,
Chan Queenie,
Wu Ed X.,
Law Wailun,
Liu Rico Kingyin,
Zhang Jingbo
Publication year - 2011
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.22405
Subject(s) - positron emission tomography , computed tomography , medicine , tomography , nuclear medicine , positron emission tomography computed tomography , radiology , computed tomography laser mammography , colorectal cancer , magnetic resonance imaging , dynamic contrast , positron emission , preclinical imaging , contrast (vision) , cancer , physics , optics , microbiology and biotechnology , biology , in vivo
Purpose To assess the correlations between parameters measured on dynamic contrast‐enhanced magnetic resonance imaging and 18F‐fluorodeoxyglucose positron emission tomography (FDG‐PET) in rectal cancer. Materials and Methods To assess the correlations between parameters measured on dynamic contrast‐enhanced MRI and FDG‐PET in rectal cancer. Results Significant correlations were only demonstrated between k ep and SUVmax (r = 0.587, P = 0.001), and k ep and SUVmean (r = 0.562, P = 0.002). No significant differences were found in imaging parameters between well, moderately and poorly differentiated adenocarcinoma groups. However, there was a trend that higher imaging values were found in poorly differentiated adenocarcinomas. Conclusion Positive correlations were found between k ep and SUV values in primary rectal adenocarcinomas suggesting an association between angiogenesis and metabolic activity and further reflecting that angiogenic activity in washout phase is better associated with tumor metabolism than the uptake phase. J. Magn. Reson. Imaging 2011;33:340–347. © 2011 Wiley‐Liss, Inc.