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Correlation of the apparent diffusion coefficient value and dynamic magnetic resonance imaging findings with prognostic factors in invasive ductal carcinoma
Author(s) -
Jeh Su Kyung,
Kim Sung Hun,
Kim Hyeon Sook,
Kang Bong Joo,
Jeong Seung Hee,
Yim Hyeon Woo,
Song Byung Joo
Publication year - 2011
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.22400
Subject(s) - effective diffusion coefficient , medicine , magnetic resonance imaging , mann–whitney u test , nuclear medicine , breast cancer , lymph node , estrogen receptor , radiology , pathology , cancer
Purpose To evaluate the correlation of the mean and minimal apparent diffusion coefficient values (ADC mean , ADC minimal ) and dynamic magnetic resonance imaging (MRI) findings with prognostic factors in invasive ductal carcinoma. Materials and Methods A total of 107 women with invasive ductal cancer underwent breast MRI. The ADC mean and ADC minimal of the cancers were computed. MRI findings were retrospectively evaluated according to the Breast Imaging Reporting and Data System (BI‐RADS) lexicon: mass or nonmass type, mass shape, mass margin, nonmass distribution, and enhancement pattern. Histological records were reviewed for tumor size, lymph node metastasis, histologic grade, and expression of estrogen receptors (ER), progesterone receptors (PR), c‐erbB‐2(HER2), Ki‐67, and epidermal growth factor receptors (EGFR). Correlations of ADC values and MR findings with prognostic factors were determined using the Mann–Whitney U ‐test and the Kruskal–Wallis test. Results The mean ADC minimal was 0.78 ± 0.24 (×10 −3 mm 2 /s), and the mean ADC mean was 1.01 ± 0.23 (×10 −3 mm 2 /s). There was a significant correlation of the ADC mean value with ER expression ( P = 0.027) and HER2 expression ( P = 0.018). There was no significant relationship between ADC minimal and prognostic factors or between ADC mean and traditional prognostic factors, PR, Ki‐67 and EGFR. The majority of the mass type lesions were less than 5 cm in size and the majority of nonmass type lesions were more than 2 cm in size ( P = 0.022). The margin of mass was significantly associated with lymph node metastasis ( P = 0.031), ER expression ( P = 0.013), PR expression ( P = 0.036), HER2 expression ( P = 0.019), and EGRF expression ( P = 0.041). The rim internal enhancement was significantly correlated with Ki‐67 expression ( P = 0.008). Conclusion The low ADC mean value was related to positive expression of ER and negative expression of HER2. A spiculated margin was related to a good prognosis, but rim enhancement was associated with a poor prognosis. J. Magn. Reson. Imaging 2011;33:102–109. © 2010 Wiley‐Liss, Inc.