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Distribution of cardiac iron measured by magnetic resonance imaging (MRI)‐R* 2
Author(s) -
Yamamura Jin,
Grosse Regine,
Graessner Joachim,
Janka Gritta E.,
Adam Gerhard,
Fischer Roland
Publication year - 2010
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.22364
Subject(s) - magnetic resonance imaging , interventricular septum , medicine , nuclear medicine , distribution (mathematics) , cardiac magnetic resonance imaging , nuclear magnetic resonance , cardiology , radiology , physics , mathematics , mathematical analysis , ventricle
Purpose To assess regional iron distribution by magnetic resonance imaging (MRI)‐R 2 * within the heart of patients with β‐thalassemia major (TM) and other iron overload diseases. Materials and Methods Breathhold electrocardiogram (ECG)‐gated MRI (1.5 T) of the heart was used for the measurement of transverse relaxation rates R 2 * in 32 patients (11–79 years). In a mid‐papillary short‐axis slice divided into septal, anterior, lateral, and posterior quadrants, R 2 * was analyzed from region of interest (ROI)‐based signal intensities from 12 echo times (TE = 1.3–26 msec). Typical boundary effects were evaluated in detail. Results The segmentation of the cardiac wall resulted in highly significant correlations of R 2 * between septal and all other quadrants. In the patient group with R 2 * < 50 s −1 (normal), all quadrants show higher normalized median rates (126%–174%) than the septum ( P < 10 −4 ), while this was relatively smaller in the group with septal R 2 * > 50 s −1 . Typical boundary effects on segmental R 2 * from blood, lung tissue, epicardial fat, and hepatic iron could not be easily separated from segmental iron distribution. Conclusion The measurement of MRI‐R2* in the interventricular septum is the least affected method by boundary effects to detect patients with iron overload at risk of developing heart failure. J. Magn. Reson. Imaging 2010;32:1104–1109. © 2010 Wiley‐Liss, Inc.