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Measurement of gas transport kinetics in high‐frequency oscillatory ventilation (HFOV) of the lung using hyperpolarized 3 He magnetic resonance imaging
Author(s) -
Terekhov Maxim,
Rivoire Julien,
Scholz Alexander,
Wolf Ursula,
Karpuk Sergei,
Salhi Zahir,
Koebrich Rainer,
David Matthias,
Schreiber Laura Maria
Publication year - 2010
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.22318
Subject(s) - magnetic resonance imaging , medicine , lung , radiology
Purpose To protect the patient with acute respiratory distress syndrome from ventilator associated lung injury (VALI) high‐frequency oscillatory ventilation (HFOV) is used. Clinical experience has proven that HFOV is an efficient therapy when conventional artificial ventilation is insufficient. However, the optimal settings of HFOV parameters, eg, tidal volumes, pressure amplitudes and frequency for maximal lung protection, and efficient gas exchange are not established unambiguously. Methods In this work magnetic resonance imaging (MRI) with hyperpolarized 3 He was employed to visualize the redistribution of gas within the cadaver pig lung during HFOV. The saturated slice method was used to characterize fast gas kinetics. Results The strong differences in kinetics were observed for HFOV‐driven gas exchange in comparison with diffusive gas transport (apnea). The significant regional and HFOV frequency dependence was detected for washout and gas exchange within the lungs. Gas redistribution was much faster in posterior than in anterior parts of the lungs during HFOV, in contrast to minor differences with an opposite trend observed in apnea. Conclusion The method shows significant potential for visualization and quantification of gas redistribution under HFOV and may help in optimization of the parameters to improve the clinical effect of HFOV for patients. J. Magn. Reson. Imaging 2010;32:887–894. © 2010 Wiley‐Liss, Inc.