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T 1ρ and T 2 quantitative magnetic resonance imaging analysis of cartilage regeneration following microfracture and mosaicplasty cartilage resurfacing procedures
Author(s) -
Holtzman Daniel J,
Theologis Alexander A,
CarballidoGamio Julio,
Majumdar Sharmila,
Li Xiaojuan,
Benjamin C.
Publication year - 2010
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.22300
Subject(s) - magnetic resonance imaging , cartilage , medicine , regeneration (biology) , radiology , anatomy , biology , microbiology and biotechnology
Purpose To examine T 1ρ (T1rho) and T 2 quantitative magnetic resonance imaging (MRI) in evaluating cartilage regeneration following microfracture (MFx) and mosaicplasty (MOS) cartilage resurfacing procedures. Materials and Methods Eighteen patients underwent MFx and eight patients underwent MOS to treat symptomatic focal cartilage defects. Quantitative T 1ρ and T 2 maps were acquired at 3–6 months and 1 year after surgery. The area of resurfacing was identified, and T 1ρ and T 2 values for the regenerated tissue (RT) and normal cartilage (NC) were acquired. RT/NC ratios were calculated to standardize absolute T 1ρ and T 2 values. Data were prospective, cross‐sectional, and nonrandomized. Results T 1ρ and T 2 showed good reanalysis reproducibility for RT and NC. Significant differences between RT and NC were present following MFx at 3–6 months for T 1ρ and T 2 values as well as following MOS at 3–6 months and 1 year for T 1ρ values. Following MFx, the T 2 RT/NC ratio was significantly different between 3–6 months and 1 year (P = 0.02), while the T 1ρ RT/NC ratio approached significance (P = 0.07). Following MOS, the T 1ρ and T 2 RT/NC ratios were not significantly different between the two timepoints. Conclusion T 1ρ and T 2 MRI are complementary and reproducible methods for quantitatively and noninvasively monitoring regeneration of RT following MFx and MOS. J. Magn. Reson. Imaging 2010;32:914–923. © 2010 Wiley‐Liss, Inc.