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Multiple‐bolus dynamic contrast‐enhanced MRI in the pancreas during a glucose challenge
Author(s) -
Naish J.H.,
Hutchinson C.E.,
Caunce A.,
Roberts C.,
Waterton J.C.,
Hockings P.D.,
Taylor C.J.,
Parker G.J.M.
Publication year - 2010
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.22281
Subject(s) - bolus (digestion) , medicine , magnetic resonance imaging , pancreas , nuclear medicine , reproducibility , dynamic contrast enhanced mri , intravenous bolus , radiology , dynamic contrast , diabetes mellitus , endocrinology , mathematics , statistics
Purpose: To assess the feasibility of multiple‐bolus dynamic contrast‐enhanced (DCE) magnetic resonance imaging (MRI) in the pancreas; to optimize the analysis; and to investigate application of the method to a glucose challenge in type 2 diabetes. Materials and Methods: A 4‐bolus DCE‐MRI protocol was performed on five patients with type 2 diabetes and 11 healthy volunteers during free‐breathing. Motion during the dynamic time series was corrected for using a model‐driven nonlinear registration. A glucose challenge was administered intravenously between the first and second DCE‐MRI acquisition in all patients and in seven of the healthy controls. Results: Image registration improved the reproducibility of the DCE‐MRI model parameters across the repeated bolus‐acquisitions in the healthy controls with no glucose challenge (eg, coefficient of variation for K trans improved from 38% to 28%). Native tissue T 1 was significantly lower in patients (374 ± 68 msec) compared with volunteers (519 ± 41 msec) but there was no significant difference in any of the baseline DCE‐MRI parameters. No effect of glucose challenge was observed in either the patients or healthy volunteers. Conclusion: Multiple bolus DCE‐MRI is feasible in the pancreas and is improved by nonlinear image registration but is not sensitive to the effects of an intravenous glucose challenge. J. Magn. Reson. Imaging 2010;32:622–628. © 2010 Wiley‐Liss, Inc.