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International reproducibility of single breathhold T2* MR for cardiac and liver iron assessment among five thalassemia centers
Author(s) -
Kirk Paul,
He Taigang,
Anderson Lisa J.,
Roughton Michael,
Tanner Mark A.,
Lam Wynnie W.M.,
Au Wing Y.,
Chu Winnie C.W.,
Chan Godfrey,
Galanello Renzo,
Matta Gildo,
Fogel Mark,
Cohen Alan R.,
Tan Ru San,
Chen Kevin,
Ng Ivy,
Lai Angie,
Fucharoen Suthat,
Laothamata Jiraporn,
Chuncharunee Suporn,
Jongjirasiri Sutipong,
Firmin David N.,
Smith Gillian C.,
Pennell Dudley J.
Publication year - 2010
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.22245
Subject(s) - reproducibility , medicine , siderosis , nuclear medicine , radiology , pathology , mathematics , statistics
Purpose: To examine the reproducibility of the single breathhold T2* technique from different scanners, after installation of standard methodology in five international centers. Materials and Methods: Up to 10 patients from each center were scanned twice locally for local interstudy reproducibility of heart and liver T2*, and then flown to a central MR facility to be rescanned on a reference scanner for intercenter reproducibility. Interobserver reproducibility for all scans was also assessed. Results: Of the 49 patients scanned, the intercenter reproducibility for T2* was 5.9% for the heart and 5.8% for the liver. Local interstudy reproducibility for T2* was 7.4% for the heart and 4.6% for the liver. Interobserver reproducibility for T2* was 5.4% for the heart and 4.4% for the liver. Conclusion: These data indicate that T2* MR may be developed into a widespread test for tissue siderosis providing that well‐defined and approved imaging and analysis techniques are used. J. Magn. Reson. Imaging 2010;32:315–319. © 2010 Wiley‐Liss, Inc.