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Effect of Gd‐EOB‐DTPA on T2‐weighted and diffusion‐weighted images for the diagnosis of hepatocellular carcinoma
Author(s) -
Saito Kazuhiro,
Araki Yoichi,
Park Jinho,
Metoki Ryo,
Katsuyama Hiroaki,
Nishio Ryota,
Kakizaki Dai,
Moriyasu Fuminori,
Tokuuye Koichi
Publication year - 2010
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.22219
Subject(s) - hepatocellular carcinoma , medicine , gadolinium , nuclear medicine , diffusion mri , liver parenchyma , magnetic resonance imaging , contrast to noise ratio , effective diffusion coefficient , imaging phantom , parenchyma , t2 weighted , contrast medium , radiology , pathology , chemistry , image quality , organic chemistry , artificial intelligence , computer science , image (mathematics)
Purpose: To evaluate the effect of gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd‐EOB‐DTPA) on T2‐weighted imaging (T2WI) and diffusion‐weighted imaging (DWI) for the diagnosis of hepatocellular carcinoma (HCC). Materials and Methods: The phantom signal intensity was measured. We also evaluated 72 patients including 30 patients with HCC. T2WI and DWI were obtained before and then 4 and 20 min after injecting the contrast medium. The signal to noise ratio (SNR), contrast to noise ratio (CNR), and apparent diffusion coefficient (ADC) were calculated in the tumor and liver parenchyma. Results: The phantom signal intensity increased on T2WI at a concentration of contrast medium less than 0.2 mmol/L but decreased when the concentration exceeded 0.4 mmol/L. SNR of the liver parenchyma on T2WI was significantly different between before and 4 min after injecting the contrast medium, while there were no significant differences between before and 4 and 20 min after injection. On T2WI, SNR, and CNR of HCC showed no significant differences at any time. SNR, CNR, and ADC of the liver parenchyma and tumor on DWI also showed no significant differences at any time. Conclusion: It is acceptable to perform T2WI and DWI after injection of Gd‐EOB‐DTPA for the diagnosis of HCC. J. Magn. Reson. Imaging 2010;32:229–234. © 2010 Wiley‐Liss, Inc.