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Preoperative detection of prostate cancer: A comparison with 11 C‐choline PET, 18 F‐fluorodeoxyglucose PET and MR imaging
Author(s) -
Watanabe Haruo,
Kanematsu Masayuki,
Kondo Hiroshi,
Kako Nobuo,
Yamamoto Naoki,
Yamada Toru,
Goshima Satoshi,
Hoshi Hiroaki,
Bae Kyongtae T.
Publication year - 2010
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.22157
Subject(s) - nuclear medicine , medicine , prostate cancer , positron emission tomography , receiver operating characteristic , mcnemar's test , fluorodeoxyglucose , magnetic resonance imaging , prostate , cancer detection , radiology , cancer , statistics , mathematics
Purpose: To compare 11 C‐choline positron emission tomography (C‐PET), 18 F‐fluorodeoxyglucose PET (FDG‐PET), and MR imaging in the preoperative detection of prostate cancer. Materials and Methods: C‐PET, FDG‐PET, and MR images were obtained in 43 consecutive patients with suspected prostate cancer, and prostate cancers were histopathologically confirmed in 26 patients. Unenhanced T1‐weighted, T2‐weighted, and gadolinium‐enhanced MR images were obtained. C‐PET and FDG‐PET were conducted 1.5 and 60 minutes after injection of 5.5 and 5.0 MBq/kg tracers, respectively. A nuclear and a genitourinary radiologist retrospectively reviewed PET and MR images at random, respectively, and assigned a confidence level for the presence of prostate cancer using a four‐point scale. Diagnostic performance was tested using the McNemar test and receiver operating characteristic curve analysis. Results: The sensitivity was greater ( P < 0.05) with MR (88%) and C‐PET (73%) images than with FDG‐PET images (31%). The accuracy was greater ( P < 0.05) with MR images (88%) than with C‐PET (67%) and FDG‐PET (53%) images. The area‐under‐curve value with MR (0.90) was greater than those with C‐PET (0.53) and FDG‐PET (0.54) images ( P < 0.01). Conclusion: MR imaging should be primarily performed in the preoperative detection of prostate cancer. C‐PET and FDG‐PET did not improve the detection. J. Magn. Reson. Imaging 2010;31:1151–1156. © 2010 Wiley‐Liss, Inc.