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Artifact‐reduced two‐dimensional cine steady state free precession for myocardial blood‐ oxygen‐level‐dependent imaging
Author(s) -
Zhou Xiangzhi,
Tsaftaris Sotirios A.,
Liu Ying,
Tang Richard,
Klein Rachel,
Zuehlsdorff Sven,
Li Debiao,
Dharmakumar Rohan
Publication year - 2010
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.22116
Subject(s) - artifact (error) , precession , steady state free precession imaging , oxygen , blood oxygen level dependent , steady state (chemistry) , magnetic resonance imaging , cardiology , nuclear magnetic resonance , medicine , nuclear medicine , physics , radiology , computer science , chemistry , artificial intelligence , quantum mechanics , astronomy
Purpose: To minimize image artifacts in long TR cardiac phase‐resolved steady state free precession (SSFP) based blood‐oxygen‐level‐dependent (BOLD) imaging. Materials and Methods: Nine healthy dogs (four male, five female, 20–25 kg) were studied in a clinical 1.5 Tesla MRI scanner to investigate the effect of temporal resolution, readout bandwidth, and motion compensation on long repetition time (TR) SSFP images. Breath‐held 2D SSFP cine sequences with various temporal resolutions (10–204 ms), bandwidths (239–930 Hz/pixel), with and without first‐order motion compensation were prescribed in the basal, mid‐ventricular, and apical along the short axis. Preliminary myocardial BOLD studies in dogs with controllable coronary stenosis were performed to assess the benefits of artifact‐reduction strategies. Results: Shortening the readout time by means of increasing readout bandwidth had no observable reduction in image artifacts. However, increasing the temporal resolution in the presence of first‐order motion compensation led to significant reduction in image artifacts. Preliminary studies demonstrated that BOLD signal changes can be reliably detected throughout the cardiac cycle. Conclusion: Artifact‐reduction methods used in this study provide significant improvement in image quality compared with conventional long TR SSFP BOLD MRI. It is envisioned that the methods proposed here may enable reliable detection of myocardial oxygenation changes throughout the cardiac cycle with long TR SSFP‐based myocardial BOLD MRI. J. Magn. Reson. Imaging 2010;31:863–871. ©2010 Wiley‐Liss, Inc.