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Consistency of signal intensity and T2* in frozen ex vivo heart muscle, kidney, and liver tissue
Author(s) -
Kaye Elena A.,
Josan Sonal,
Lu Aiming,
Rosenberg Jarrett,
Daniel Bruce L.,
Pauly Kim Butts
Publication year - 2010
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.22029
Subject(s) - ex vivo , consistency (knowledge bases) , kidney , intensity (physics) , in vivo , medicine , anatomy , biology , computer science , physics , quantum mechanics , artificial intelligence , microbiology and biotechnology
Purpose: To investigate tissue dependence of the MRI‐based thermometry in frozen tissue by quantification and comparison of signal intensity and T2* of ex vivo frozen tissue of three different types: heart muscle, kidney, and liver. Materials and Methods: Tissue samples were frozen and imaged on a 0.5 Tesla MRI scanner with ultrashort echo time (UTE) sequence. Signal intensity and T2* were determined as the temperature of the tissue samples was decreased from room temperature to approximately −40°C. Statistical analysis was performed for (−20°C, −5°C) temperature interval. Results: The findings of this study demonstrate that signal intensity and T2* are consistent across three types of tissue for (−20°C, −5°C) temperature interval. Conclusion: Both parameters can be used to calculate a single temperature calibration curve for all three types of tissue and potentially in the future serve as a foundation for tissue‐independent MRI‐based thermometry. J. Magn. Reson. Imaging 2010;31:719–724. © 2010 Wiley‐Liss, Inc.