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Highly accelerated first‐pass contrast‐enhanced magnetic resonance angiography of the peripheral vasculature: Comparison of gadofosveset trisodium with gadopentetate dimeglumine contrast agents
Author(s) -
Maki Jeffrey H.,
Wang Maisie,
Wilson Gregory J.,
Shutske Matthew G.,
Leiner Tim
Publication year - 2009
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.21961
Subject(s) - medicine , magnetic resonance angiography , nuclear medicine , meglumine , trisodium citrate , contrast (vision) , image quality , gadolinium , radiology , magnetic resonance imaging , angiography , gadolinium dtpa , materials science , artificial intelligence , computer science , metallurgy , image (mathematics) , biochemistry , chemistry
Purpose: To investigate the blood pool agent gadofosveset trisodium for first‐pass, dynamic peripheral contrast‐enhanced magnetic resonance angiography (pMRA), and compare the results with a conventional gadolinium contrast agent. Materials and Methods: A total of 16 patients were imaged at 1.5T using a prototype peripheral vascular coil with high SENSE acceleration. Five received gadopentetate dimeglumine (≈0.25 mmol/kg), and 11 received gadofosveset trisodium (five standard‐dose 0.03 mmol/kg, six high‐dose 0.05 mmol/kg). Quantitative contrast‐enhancement and qualitative image quality evaluation was compared between agents and doses. Results: High‐quality diagnostic images were uniformly obtained. The contrast ratio did not significantly differ between gadopentetate dimeglumine and high‐dose gadofosveset trisodium, both of which were greater than standard‐dose gadofosveset trisodium. High‐dose gadofosveset trisodium was equivalent to gadopentetate dimeglumine in image quality and subjective vessel‐to‐background ratio, but significantly better for depicting small muscular arteries. Standard‐dose gadofosveset trisodium showed equivalent image quality and small artery depiction with a slight but significant decrease in vessel‐to‐background ratio as compared to gadopentatate dimeglumine. Both gadofosveset trisodium doses trended toward more venous enhancement, but this was not a diagnostic problem. Conclusion: First‐pass peripheral CE‐MRA using gadofosveset trisodium is feasible, yielding image quality comparable to double to triple‐dose gadopentetate dimeglumine. Increasing the gadofosveset trisodium dose to 0.05 mmol/kg yields further improvements. J. Magn. Reson. Imaging 2009;30:1085–1092. © 2009 Wiley‐Liss, Inc.