Measurement of R1 dynamics using sliding window‐DESPOT | Zendy

Schulz Jessica | Zendy; Korn Matthias | Zendy; Woenne Eva C. | Zendy; Umathum Reiner | Zendy; Briel Andreas | Zendy; Hengerer Arne | Zendy; Semmler Wolfhard | Zendy; Bock Michael | Zendy

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Measurement of R1 dynamics using sliding window‐DESPOT

Author(s) -

Schulz Jessica,

Korn Matthias,

Woenne Eva C.,

Umathum Reiner,

Briel Andreas,

Hengerer Arne,

Semmler Wolfhard,

Bock Michael

Publication year - 2009

Publication title -

journal of magnetic resonance imaging

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.563

H-Index - 160

eISSN - 1522-2586

pISSN - 1053-1807

DOI - 10.1002/jmri.21946

Subject(s) - temporal resolution , contrast (vision) , window (computing) , relaxation (psychology) , dynamics (music) , sliding window protocol , data set , resolution (logic) , measure (data warehouse) , nuclear magnetic resonance , computer science , physics , artificial intelligence , optics , data mining , acoustics , biology , neuroscience , operating system

Purpose: To measure longitudinal relaxation rate (R1) changes during contrast agent studies using a driven equilibrium single pulse observation of T1 (DESPOT) method with a sliding window (sw) acquisition. Materials and Methods: A sw‐DESPOT technique was implemented that uses several three‐dimensional (3D) image data sets to calculate R1 with a temporal resolution of only a single data set. Different sources of systematic errors were studied in simulations, and the technique was tested in a tumor‐bearing mouse using an intravascular contrast agent. Results: Consistent concentration distributions of the CA were calculated with a temporal resolution of 10 s. Conclusion: Sw‐DESPOT offers a precise and fast method to monitor the CA dynamics in 3D volumes. J. Magn. Reson. Imaging 2009;30:1163–1170. © 2009 Wiley‐Liss, Inc.

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