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Measurement of R1 dynamics using sliding window‐DESPOT
Author(s) -
Schulz Jessica,
Korn Matthias,
Woenne Eva C.,
Umathum Reiner,
Briel Andreas,
Hengerer Arne,
Semmler Wolfhard,
Bock Michael
Publication year - 2009
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.21946
Subject(s) - temporal resolution , contrast (vision) , window (computing) , relaxation (psychology) , dynamics (music) , sliding window protocol , data set , resolution (logic) , measure (data warehouse) , nuclear magnetic resonance , computer science , physics , artificial intelligence , optics , data mining , acoustics , biology , neuroscience , operating system
Abstract Purpose: To measure longitudinal relaxation rate (R1) changes during contrast agent studies using a driven equilibrium single pulse observation of T1 (DESPOT) method with a sliding window (sw) acquisition. Materials and Methods: A sw‐DESPOT technique was implemented that uses several three‐dimensional (3D) image data sets to calculate R1 with a temporal resolution of only a single data set. Different sources of systematic errors were studied in simulations, and the technique was tested in a tumor‐bearing mouse using an intravascular contrast agent. Results: Consistent concentration distributions of the CA were calculated with a temporal resolution of 10 s. Conclusion: Sw‐DESPOT offers a precise and fast method to monitor the CA dynamics in 3D volumes. J. Magn. Reson. Imaging 2009;30:1163–1170. © 2009 Wiley‐Liss, Inc.