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High resolution fast T1 mapping technique for dGEMRIC
Author(s) -
Sur Samir,
Mamisch Tallal Charles,
Hughes Timothy,
Kim YoungJo
Publication year - 2009
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.21869
Subject(s) - resolution (logic) , articular cartilage , osteoarthritis , sequence (biology) , high resolution , nuclear medicine , cartilage , image resolution , cartilage damage , magnetic resonance imaging , medicine , gadolinium , isotropy , biomedical engineering , radiology , materials science , anatomy , geology , computer science , artificial intelligence , physics , chemistry , pathology , optics , biochemistry , alternative medicine , remote sensing , metallurgy
Purpose To determine the feasibility of using a high resolution isotropic three‐dimensional (3D) fast T1 mapping sequence for delayed gadolinium‐enhanced MRI of cartilage (dGEMRIC) to assess osteoarthritis in the hip. Materials and Methods T1 maps of the hip were acquired using both low and high resolution techniques following the administration of 0.2 mmol/kg Gd‐DTPA 2‐ in 35 patients. Both T1 maps were generated from two separate spoiled GRE images. The high resolution T1 map was reconstructed in the anatomically equivalent plane as the low resolution map. T1 values from the equivalent anatomic regions containing femoral and acetabular cartilages were measured on the low and high resolution maps and compared using regression analysis. Results In vivo T1 measurements showed a statistically significant correlation between the low and high resolution acquisitions at 1.5 Tesla (R 2 = 0.958, P < 0.001). These results demonstrate the feasibility of using a fast two‐angle T1 mapping (F2T1) sequence with isotropic spatial resolution (0.8 × 0.8 × 0.8 mm) for quantitative assessment of biochemical status in articular cartilage of the hip. Conclusion The high resolution 3D F2T1 sequence provides accurate T1 measurements in femoral and acetabular cartilages of the hip, which enables the biochemical assessment of articular cartilage in any plane through the joint. It is a powerful tool for researchers and clinicians to acquire high resolution data in a reasonable scan time (< 30 min). J. Magn. Reson. Imaging 2009;30:896–900. © 2009 Wiley‐Liss, Inc.