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Magnetic resonance (MR) differential diagnosis of breast tumors using apparent diffusion coefficient (ADC) on 1.5‐T
Author(s) -
Tsushima Yoshito,
TakahashiTaketomi Ayako,
Endo Keigo
Publication year - 2009
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.21854
Subject(s) - effective diffusion coefficient , medicine , confidence interval , diffusion mri , nuclear medicine , breast cancer , magnetic resonance imaging , differential diagnosis , radiology , pathology , cancer
Abstract To review the published reports concerning the apparent diffusion coefficient (ADC) value evaluation for the differentiation between malignant and benign breast tumors, articles were searched with the inclusion criteria: (a) a 1.5‐T unit was used; (b) the diagnostic criteria were clearly stated; (c) diffusion‐weighted images (DWIs) were obtained, and ADC value was calculated; (d) ADC values of breast tumors were reported with mean ± standard deviation (SD). Meta‐analysis from 12 articles revealed that the pooled sensitivity and specificity were 0.89 (95% confidence interval [CI], 0.85–0.91) and 0.77 (95% CI, 0.69–0.84), respectively, and that only the maximum b factor correlated with the mean ADC values of malignant and benign tumors, and the noncancerous breast tissue ( P < 0.05, P < 0.01, P < 0.05, respectively). In conclusion, ADC evaluation is useful for the differentiation between malignant and benign breast tumors. J. Magn. Reson. Imaging 2009;30:249–255. © 2009 Wiley‐Liss, Inc.