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Temporal sampling requirements for reference region modeling of DCE‐MRI data in human breast cancer
Author(s) -
Planey Catherine R.,
Welch E. Brian,
Xu Lei,
Chakravarthy A. Bapsi,
Gatenby J. Christopher,
Freehardt Darla,
Mayer Ingrid,
Meszeoly Ingrid,
Kelley Mark,
MeansPowell Julie,
Gore John C.,
Yankeelov Thomas E.
Publication year - 2009
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.21812
Subject(s) - confidence interval , breast cancer , correlation , sampling (signal processing) , temporal resolution , nuclear medicine , medicine , data sampling , statistics , cancer , mathematics , computer science , artificial intelligence , physics , geometry , filter (signal processing) , quantum mechanics , computer vision
Purpose To assess the temporal sampling requirements needed for quantitative analysis of dynamic contrast‐enhanced MRI (DCE‐MRI) data with a reference region (RR) model in human breast cancer. Materials and Methods Simulations were used to study errors in pharmacokinetic parameters ( K trans and v e ) estimated by the RR model using six DCE‐MRI acquisitions over a range of pharmacokinetic parameter values, arterial input functions, and temporal samplings. DCE‐MRI data were acquired on 12 breast cancer patients and parameters were estimated using the native resolution data (16.4 seconds) and compared to downsampled 32.8‐second and 65.6‐second data. Results Simulations show that, in the majority of parameter combinations, the RR model results in an error less than 20% in the extracted parameters with temporal sampling as poor as 35.6 seconds. The experimental results show a high correlation between K trans and v e estimates from data acquired at 16.4‐second temporal resolution compared to the downsampled 32.8‐second data: the slope of the regression line was 1.025 (95% confidence interval [CI]: 1.021, 1.029), Pearson's correlation r = 0.943 (95% CI: 0.940, 0.945) for K trans , and 1.023 (95% CI: 1.021. 1.025), r = 0.979 (95% CI: 0.978, 0.980) for v e . For the 64‐second temporal resolution data the results were: 0.890 (95% CI: 0.894, 0.905), r = 0.8645, (95% CI: 0.858, 0.871) for K trans , and 1.041 (95% CI: 1.039, 1.043), r = 0.970 (95% CI: 0.968, 0.971) for v e . Conclusion RR analysis allows for a significant reduction in temporal sampling requirements and this lends itself to analyze DCE‐MRI data acquired in practical situations. J. Magn. Reson. Imaging 2009;30:121–134. © 2009 Wiley‐Liss, Inc.