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Combining spatial and temporal information to explore function‐guide action of acupuncture using fMRI
Author(s) -
Liu Peng,
Qin Wei,
Zhang Yi,
Tian Jie,
Bai Lijun,
Zhou Guangyu,
Liu Jixin,
Chen Peng,
Dai Jianping,
von Deneen Karen M.,
Liu Yijun
Publication year - 2009
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.21805
Subject(s) - precuneus , default mode network , posterior cingulate , neuroscience , brain activity and meditation , electroacupuncture , pattern recognition (psychology) , psychology , functional connectivity , computer science , acupuncture , medicine , artificial intelligence , functional magnetic resonance imaging , electroencephalography , pathology , alternative medicine
Purpose To investigate the brain response patterns of modulation of GB37 (Guangming) and KI8 (Jiaoxin). Materials and Methods An experiment using nonrepeated event‐related fMRI design was carried out on 28 subjects with electroacupuncture stimulation (EAS) at GB37 or KI8 on the left leg. The discrete cosine transform and functional connectivity methods were adopted to detect the differences related with these two acupoints before and after the EAS. Results Spatial patterns were distinct for EAS at the two acupoints, and the overlapping brain regions were mainly located in the posterior cingulate cortex (PCC) and precuneus (pC). Two opposite patterns of modulation in the default mode network were detected from the temporal patterns with the overlapping PCC/pC as the region of interest. Furthermore, the specific responses of sustained effects at these acupoints were also identified. Conclusion Spatial and temporal patterns of the sustained effect modulation of GB37 and KI8 were distinct. We suggest these findings may attribute to the functional specificity of a certain acupoint. Moreover, our current results reflect a significant methodological contribution to future acupuncture studies. J. Magn. Reson. Imaging 2009;30:41–46. © 2009 Wiley‐Liss, Inc.