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Multicenter validation of the magnetic resonance t2* technique for segmental and global quantification of myocardial iron
Author(s) -
Ramazzotti Anna,
Pepe Alessia,
Positano Vincenzo,
Rossi Giuseppe,
De Marchi Daniele,
Brizi Maria Gabriella,
Luciani Antongiulio,
Midiri Massimo,
Sallustio Giuseppina,
Valeri Gianluca,
Caruso Vincenzo,
Centra Michele,
Cianciulli Paolo,
De Sanctis Vincenzo,
Maggio Aurelio,
Lombardi Massimo
Publication year - 2009
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.21781
Subject(s) - intraclass correlation , reproducibility , multislice , nuclear medicine , magnetic resonance imaging , medicine , nuclear magnetic resonance , coefficient of variation , multislice computed tomography , radiology , mathematics , computed tomography , physics , statistics
Purpose To assess the transferability of the magnetic resonance imaging (MRI) multislice multiecho T2* technique for global and segmental measurement of iron overload in thalassemia patients. Materials and Methods Multiecho T2* sequences were installed on six MRI scanners. Five healthy subjects ( n = 30) were scanned at each site; five thalassemia major (TM) patients were scanned at the reference site and were rescanned locally ( n = 25) within 1 month. T2* images were analyzed using previously validated software. Results T2* values of healthy subjects showed intersite homogeneity. On TM patients, for global heart T2* values the correlation coefficient was 0.97, coefficients of variation (CoV s ) ranged from 0.04–0.12, and intraclass coefficients (ICC s ) ranged from 0.94–0.99. The mean CoV and ICC for segmental T2* distribution were 0.198 and 88, respectively. Conclusion The multislice multiecho T2* technique is transferable among scanners with good reproducibility. J. Magn. Reson. Imaging 2009;30:62–68. © 2009 Wiley‐Liss, Inc.