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Reproducibility of MR perfusion and 1 H spectroscopy of bone marrow
Author(s) -
Griffith James F.,
Yeung David K.W.,
Chow Steven K.K.,
Leung Jason Chi Shun,
Leung Ping Chung
Publication year - 2009
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.21765
Subject(s) - reproducibility , perfusion , nuclear medicine , medicine , femoral head , dynamic contrast , bone marrow , magnetic resonance imaging , in vivo magnetic resonance spectroscopy , radiology , pathology , chemistry , anatomy , chromatography
Purpose To determine the reproducibility of proton ( 1 H) magnetic resonance (MR) spectroscopy and dynamic contrast‐enhanced MR imaging in a clinical setting for the assessment of marrow fat fraction and marrow perfusion in longitudinal studies. Materials and Methods In all, 36 subjects (17 females, 19 males, mean age 72.9 ± 2.9 years) who underwent MR spectroscopy and/or dynamic contrast‐enhanced perfusion imaging of the proximal femur were asked to return after 1 week for a repeat MR examination. Results Reproducibility of 1 H MR spectroscopy in all bone areas tested was high, ranging from 0.78–0.85, with the highest reproducibility being in the femoral head and lowest in the femoral neck. Reproducibility of paired perfusion measurements ranged from 0.59 (enhancement slope femoral head) to 0.98 (enhancement maximum acetabulum). Overall reproducibility of 1 H MR spectroscopy and dynamic contrast‐enhanced imaging tended to be best in areas with the highest inherent fat fraction or perfusion. Conclusion Reproducibility of 1 H MR spectroscopy or perfusion imaging is sufficiently high to warrant these techniques being applied to the longitudinal study of bone diseases. J. Magn. Reson. Imaging 2009;29:1438–1442. © 2009 Wiley‐Liss, Inc.