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Comparison of spiral imaging and SENSE‐EPI at 1.5 and 3.0 T using a controlled cerebrovascular challenge
Author(s) -
Winter Jeff D.,
Poublanc Julien,
Crawley Adrian P.,
Kassner Andrea
Publication year - 2009
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.21745
Subject(s) - blood oxygen level dependent , spiral (railway) , susceptibility weighted imaging , dropout (neural networks) , neuroimaging , magnetic resonance imaging , nuclear magnetic resonance , sensitivity (control systems) , physics , medicine , neuroscience , nuclear medicine , psychology , computer science , radiology , mathematics , mathematical analysis , machine learning , electronic engineering , engineering
Purpose To quantitatively compare spiral imaging and sensitivity‐encoded‐echo‐planar‐imaging (SENSE‐EPI) methods for blood oxygen level‐dependent (BOLD) imaging using controlled changes in the end‐tidal partial pressure of CO 2 (PetCO 2 ) to provide a global BOLD response. Specifically, we examined susceptibility‐field‐gradient effects on the BOLD sensitivity throughout the brain. Materials and Methods We quantified cerebrovascular reactivity (CVR) using the BOLD response to cyclic changes in PetCO 2 in five healthy volunteers at 1.5 and 3.0 T using spiral imaging and SENSE‐EPI. We compared the two techniques with respect to susceptibility‐induced signal dropout and CVR t ‐statistic. Results Compared to spiral imaging, SENSE‐EPI significantly reduced the volume of signal dropout by 32 ± 18% at 3.0 T. In regions with large susceptibility gradients, SENSE‐EPI demonstrated a trend for a greater t ‐statistic than spiral imaging, particularly at 3.0 T. However, no statistically significant between‐technique differences existed. Conclusion The results at 3.0 T suggest that, compared with spiral imaging, SENSE‐EPI reduces signal loss associated with susceptibility field gradients in affected regions without affecting BOLD sensitivity. This study also demonstrates a unique application of controlled PetCO 2 changes to quantitatively compare BOLD techniques, which may be useful for the design of future fMRI studies. J. Magn. Reson. Imaging 2009;29:1206–1210. © 2009 Wiley‐Liss, Inc.