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Microperfusion‐induced elevation of ADC is suppressed after contrast in breast carcinoma
Author(s) -
Yuen Sachiko,
Yamada Kei,
Goto Mariko,
Nishida Kaori,
Takahata Akiko,
Nishimura Tsunehiko
Publication year - 2009
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.21743
Subject(s) - medicine , effective diffusion coefficient , nuclear medicine , breast carcinoma , contrast (vision) , radiology , magnetic resonance imaging , breast cancer , cancer , artificial intelligence , computer science
Purpose To investigate the effect of gadolinium (Gd)‐DTPA on the apparent diffusion coefficient (ADC) of breast carcinoma and to analyze the relationship between pre/postcontrast ADC and the degree of contrast enhancement. Materials and Methods Nineteen histopathologically confirmed breast carcinomas (mean size = 22 mm) were analyzed. Their ADCs before and after contrast administration were measured. The contrast‐to‐noise ratios (CNRs) of the tumors were measured on fat‐suppressed 3D T1‐weighted images in precontrast, early, and late postcontrast phases. These results were correlated with the measured ADC values. Results A significant decrease in the measured ADC was noted after contrast administration (−23%, P = 0.01). Lesions with relatively high ADC before contrast (>1.3 × 10 −3 mm 2 /sec; n = 12) demonstrated a larger degree of ADC reduction (mean 34%) than lesions with low ADC (≤1.3 × 10 −3 mm 2 /sec; n = 7) (mean 4.5%). When an early postcontrast image was used as a surrogate marker of malignant potential, we found a significant inverse correlation with postcontrast ADC (γ = −0.57, P = 0.02). Conclusion Postcontrast ADC exhibited lower values than precontrast ADC, which is thought to reflect suppression of the microperfusion‐induced effect on diffusion‐weighted imaging. Postcontrast ADC may be a better indicator than precontrast ADC to reflect malignant potential of tumors. J. Magn. Reson. Imaging 2009;29:1080–1084. © 2009 Wiley‐Liss, Inc.