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Revisiting anaplastic astrocytomas I: An expansive growth pattern is associated with a better prognosis
Author(s) -
Moulding Hugh D.,
Friedman David P.,
Curtis Mark,
Kenyon Lawrence,
Flanders Adam E.,
Paek Sun Ha,
Andrews David W.
Publication year - 2008
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.21593
Subject(s) - expansive , medicine , anaplastic astrocytoma , astrocytoma , proportional hazards model , oncology , survival analysis , multivariate analysis , stage (stratigraphy) , glioma , cancer research , biology , materials science , compressive strength , composite material , paleontology
Purpose To study whether anaplastic astrocytomas that are nonenhancing and/or well‐circumscribed (expansive) are associated with a better prognosis. Materials and Methods We retrospectively identified 59 patients with pathologically confirmed World Health Organizaiton (WHO) grade III anaplastic astrocytoma who underwent craniotomy at our institution from 1995 through 2006. We assessed prognostic variables including age, enhancement (EAA—34 patients) vs. nonenhancement (NEAA—25 patients), MR growth patterns (expansive [28 patients] vs. mixed/infiltrative [31 patients]), recursive partitioning analysis (RPA) class, resection extent, and addition of chemotherapy. Primary outcome measure was survival. Results Kaplan‐Meier curves showed improved survival in NEAA, expansive tumors, and RPA 1 class patients. Within RPA class I patients, expansive growth pattern remained a significant advantage in survival time. Examining extent of resection also showed that patients with gross total resections (GTR) had a better prognosis. A multivariate (Cox proportional hazards) analysis showed that patient age and expansive tumor phenotype affected outcome, whereas RPA class, enhancement, and GTR did not. Conclusion Circumscribed growth in histologically proven anaplastic astrocytoma, which has not been emphasized in past studies, has a considerable survival advantage. J. Magn. Reson. Imaging 2008;28:1311–1321. © 2008 Wiley‐Liss, Inc.