Premium
T1‐weighted functional imaging based on a contrast agent in presurgical mapping
Author(s) -
Ben Bashat Dafna,
Sivan Ida,
Ziv Michal,
Aizenstein Orna,
Pianka Pazit,
Malach Rafael,
Graif Moshe,
Hendler Talma,
Navon Gil
Publication year - 2008
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.21587
Subject(s) - contrast (vision) , functional imaging , blood oxygen level dependent , susceptibility weighted imaging , blood oxygenation , nuclear medicine , medicine , magnetic resonance imaging , computer science , functional magnetic resonance imaging , radiology , artificial intelligence
Purpose To assess the applicability of T1‐weighted images in the presence of a contrast agent for functional mapping free of susceptibility artifacts, in comparison to the blood oxygenation level‐dependent (BOLD) imaging. Materials and Methods Six patients and five control subjects were scanned using BOLD and T1‐weighted functional imaging, in the presence of a Gd‐DTPA contrast‐agent (TOFICA). In the control group, low‐ and high‐resolution BOLD images were performed. Functional stimuli included motor and language activations. Results Both BOLD and TOFICA methods resulted in activations in the expected anatomical regions. The TOFICA mapping gave less distributed and with higher percent signal changes in comparison with the BOLD images. Gd‐DTPA remained almost constant in the blood for at least 15 min post injection. In one patient with surgical clips, no signal was detected in the left cerebral hemisphere using BOLD imaging, but activation could be mapped using the TOFICA method. Conclusion T1‐weighted imaging in the presence of a contrast agent can be used for functional mapping. This method is insensitive to susceptibility artifacts, and is therefore advantageous in the evaluation of presurgical cases and in areas of the brain close to cavities in which the BOLD method cannot reliably be applied. J. Magn. Reson. Imaging 2008;28:1245–1250. © 2008 Wiley‐Liss, Inc.