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Comparison and reproducibility of ADC measurements in breathhold, respiratory triggered, and free‐breathing diffusion‐weighted MR imaging of the liver
Author(s) -
Kwee Thomas C.,
Takahara Taro,
Koh DowMu,
Nievelstein Rutger A.J.,
Luijten Peter R.
Publication year - 2008
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.21569
Subject(s) - medicine , reproducibility , nuclear medicine , effective diffusion coefficient , magnetic resonance imaging , respiratory system , liver parenchyma , breathing , diffusion mri , ventilation (architecture) , radiology , anatomy , chemistry , mechanical engineering , chromatography , engineering
Purpose To compare and determine the reproducibility of apparent diffusion coefficient (ADC) measurements of the normal liver parenchyma in breathhold, respiratory triggered, and free‐breathing diffusion‐weighted magnetic resonance imaging (DWI). Materials and Methods Eleven healthy volunteers underwent three series of DWI. Each DWI series consisted of one breathhold, one respiratory triggered, and two free‐breathing (thick and thin slice acquisition) scans of the liver, at b‐values of 0 and 500 s/mm 2 . ADCs of the liver parenchyma were compared by using nonparametric tests. Reproducibility was assessed by the Bland–Altman method. Results Mean ADCs (in 10 −3 mm 2 /sec) in respiratory triggered DWI (2.07–2.27) were significantly higher than mean ADCs in breathhold DWI (1.57–1.62), thick slice free‐breathing DWI (1.62–1.65), and thin slice free‐breathing DWI (1.57–1.66) ( P < 0.005). Ranges of mean difference in ADC measurement ± limits of agreement between two scans were −0.02–0.05 ± 0.16–0.24 in breathhold DWI, −0.14–0.20 ± 0.59–0.60 in respiratory triggered DWI, −0.03–0.03 ± 0.20–0.29 in thick slice free‐breathing DWI, and −0.01–0.09 ± 0.21–0.29 in thin slice free‐breathing DWI. Conclusion ADC measurements of the normal liver parenchyma in respiratory triggered DWI are significantly higher and less reproducible than in breathhold and free‐breathing DWI. J. Magn. Reson. Imaging 2008;28:1141–1148. © 2008 Wiley‐Liss, Inc.