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Dynamic perfusion MRI: Capability for evaluation of disease severity and progression of pulmonary arterial hypertension in patients with connective tissue disease
Author(s) -
Ohno Yoshiharu,
Koyama Hisanobu,
Nogami Munenobu,
Takenaka Daisuke,
Matsumoto Sumiaki,
Onishi Yumiko,
Matsumoto Keiko,
Murase Kenya,
Sugimura Kazuro
Publication year - 2008
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.21550
Subject(s) - medicine , cardiology , pulmonary hypertension , perfusion , connective tissue disease , vascular resistance , ctd , pulmonary function testing , hemodynamics , disease , autoimmune disease , oceanography , geology
Purpose To prospectively evaluate the capability of dynamic perfusion MRI for assessment of disease severity and progression to pulmonary arterial hypertension (PAH) in connective tissue disease (CTD) patients. Materials and Methods In all, 18 gender‐ and age‐matched CTD patients without and with PAH and nine healthy volunteers underwent dynamic perfusion MRI, Doppler echocardiography, and pulmonary function test. Disease severity of CTD was assessed in terms of diffusing capacity for carbon monoxide (%DL CO ) and estimated systolic pulmonary arterial pressure (sPAP), and progression of PAH in terms of pulmonary arterial pressure (mPAP) and pulmonary vascular resistance (PVR). From calculated pulmonary perfusion parameter maps, means of pulmonary blood flow (mPBF), pulmonary blood volume (mPBV), and mean transit time (mMTT) were determined as averages of all region of interest (ROI) measurements. To determine disease severity in CTD, all parameters were statistically correlated with sPAP and %DL CO . To determine progression to PAH, all parameters were statistically correlated with mPAP and PVR. Results All pulmonary perfusion parameters correlated significantly with sPAP and %DL CO ( P < 0.05). mPBF and mPBV correlated significantly with mPAP and moderately with PVR ( P < 0.05). Conclusion Dynamic perfusion MRI can be used for assessment of disease severity and progression of PAH in CTD patients. J. Magn. Reson. Imaging 2008;28:887–899. © 2008 Wiley‐Liss, Inc.