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Improvement of MRI‐functional measurement with automatic movement correction in native and transplanted kidneys
Author(s) -
de Senneville Baudouin Denis,
Mendichovszky Iosif Alexandru,
Roujol Sébastien,
Gordon Isky,
Moonen Chrit,
Grenier Nicolas
Publication year - 2008
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.21515
Subject(s) - magnetic resonance imaging , nuclear medicine , renal function , kidney , voxel , limits of agreement , mathematics , medicine , radiology
Purpose To improve 2D software for motion correction of renal dynamic contrast‐enhanced magnetic resonance imaging (DCE‐MRI) and to evaluate its effect using the Patlak–Rutland model. Materials and Methods A subpixel‐accurate method to correct for kidney motion during DCE‐MRI was evaluated on native and transplanted kidneys using data from two different institutions with different magnets and protocols. The Patlak–Rutland model was used to calculate glomerular filtration rate (GFR) on a voxel‐by‐voxel basis providing mean (K̄p) and uncertainty ( σ ( K p )) values for GFR. Results In transplanted kidneys, average absolute variation of K̄p was 6.4% ± 4.8% (max = 16.6%). In native kidneys average absolute variation of K̄p was 12.11% ± 6.88% (max = 25.6%) for the right and 11.6% ± 6% (max = 20.8%) for the left. Movement correction showed an average reduction of σ ( K p ) of 6.9% ± 6.6% (max = 21.4%) in transplanted kidneys, 30.9% ± 17.6% (max = 60.8%) for the right native kidney, and 31.8% ± 14% (max = 55.3%) for the left kidney. Conclusion The movement correction algorithm showed improved uncertainty on GFR computation for both native and transplanted kidneys despite different spatial resolution from the different MRI systems and different levels of signal‐to‐noise ratios on DCE‐MRI. J. Magn. Reson. Imaging 2008;28:970–978. © 2008 Wiley‐Liss, Inc.