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Diffusion tensor imaging and fiber tractography of C6 rat glioma
Author(s) -
Asanuma Taketoshi,
Doblas Sabrina,
Tesiram Yasvir A.,
Saunders Debra,
Cranford Rebecca,
Pearson Jamie,
Abbott Andrew,
Smith Nataliya,
Towner Rheal A.
Publication year - 2008
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.21473
Subject(s) - tractography , diffusion mri , corpus callosum , neuroscience , fiber tract , fiber , fractional anisotropy , glioma , cortex (anatomy) , biomedical engineering , magnetic resonance imaging , materials science , medicine , biology , radiology , cancer research , composite material
Purpose To apply diffusion tensor images using 30 noncollinear directions for diffusion‐weighted gradient schemes to characterize diffusion tensor imaging (DTI) features associated with C6 glioma‐bearing rat brains, and ideally visualize fiber tractography datasets. Materials and Methods Fiber tractographies of normal male Fischer 344 rat brains were constructed from DTI datasets acquired with a 30 noncollinear diffusion gradient scheme. Cultured C6 cell were intracranially injected into the cortex of male Fischer 344 rats. The time course of the tumor growth was monitored with DTI and fiber tractography using diffusion‐weighting gradients in 30 noncollinear directions. Results Fiber tractographies through the corpus callosum (CC) were easily visualized with the 30‐direction gradient scheme, and the fiber trajectories of the motor cortex and striatum were well represented in normal rats. Fiber tractography indicated that the neuronal fibers of the CC were compressed or disappeared by growing C6 glioma, which affected surrounding brain tissue. Conclusion We have demonstrated in this study that fiber tractography with the 30 noncollinear diffusion gradient scheme method can be used to help provide a better understanding regarding the influence of a tumor on the surrounding regions of normal brain tissue in vivo. J. Magn. Reson. Imaging 2008;28:566–573. © 2008 Wiley‐Liss, Inc.