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Vitamin C estimation with standard 1 H spectroscopy using a clinical 3T MR system: Detectability and reliability within the human brain
Author(s) -
Shih YiYu,
Büchert Martin,
Chung HsiaoWen,
Hennig Jürgen,
von Elverfeldt Dominik
Publication year - 2008
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.21466
Subject(s) - in vivo , in vivo magnetic resonance spectroscopy , voxel , ascorbic acid , nuclear magnetic resonance spectroscopy , reliability (semiconductor) , spectroscopy , nuclear magnetic resonance , chemistry , magnetic resonance imaging , nuclear medicine , computer science , medicine , physics , radiology , biology , artificial intelligence , power (physics) , microbiology and biotechnology , food science , quantum mechanics
Purpose To evaluate whether vitamin C is detectable using clinical routine MRS combined with LCModel analysis and verify the reliability of its estimated concentration. Materials and Methods In order to determine the reliability of the estimated ascorbic acid (Asc) concentrations, we analyzed 76 in vivo single voxel spectra (SVS) acquired on a 3T scanner (point‐resolved spectroscopy with TE = 30 ms, TR = 3000 ms, voxel size = 8 mL, without spectral editing) from different regions within the brain using LCModel. In addition to this we simulated multiple concentration levels by adding adapted Asc spectra to the in vivo data. Results Asc was successfully detected in 71 of 76 in vivo spectra with a comparable concentration ratio to that of myo‐inositol. Furthermore, we observed good linearity between added Asc concentrations and the LCModel estimates within the simulations having correlation coefficients larger than 0.985 at three different linewidth cases. Conclusion This study demonstrates the ability to detect vitamin C in the human brain under common clinical magnetic resonance spectroscopy (MRS) standards in combination with LCModel. Furthermore, it supports the need to include Asc in the standard MRS analysis. J. Magn. Reson. Imaging 2008;28:351–358. © 2008 Wiley‐Liss, Inc.