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Characterization of hepatocellular carcinoma and colorectal liver metastasis by means of perfusion MRI
Author(s) -
Abdullah Siraj Saadaldin,
Pialat Jean Baptiste,
Wiart Marlene,
Duboeuf François,
Mabrut JeanYves,
Bancel Brigitte,
Rode Agnès,
Ducerf Christian,
Baulieux Jacques,
Berthezene Yves
Publication year - 2008
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.21429
Subject(s) - perfusion , medicine , hepatocellular carcinoma , blood flow , colorectal cancer , metastasis , liver cancer , perfusion scanning , blood volume , arterial perfusion , nuclear medicine , magnetic resonance imaging , carcinoma , liver parenchyma , parenchyma , radiology , pathology , cancer
Abstract Purpose To characterize and compare hepatocellular carcinoma and liver metastases of colorectal metastatic cancer (CMC) by means of quantitative liver perfusion MRI. Materials and Methods Liver perfusion was assessed in 26 HCC and CMC patients (50 nodules) by means of contrast‐enhanced MRI. Six perfusion parameters—hepatic perfusion index ( HPI ), mean transit time ( MTT ), distribution volume ( DV ), total blood flow ( F T ), arterial blood flow ( F A ), and portal blood flow ( F P )—were calculated in tumor nodules and the adjacent hepatic parenchyma. Results The values of F T , F A , F P , and DV were significantly higher in the HCC than in the CMC group, whereas MTT was significantly higher in the CMC group. There was no significant difference in HPI . Arterial blood flow was higher than portal blood flow in the CMC group, while portal blood flow was slightly higher than arterial blood flow in the HCC group. Conclusion The present work describes the use of dynamic MRI to quantitatively assess liver perfusion, which in the future may help studying liver cancers on the basis of their microvascular characteristics. J. Magn. Reson. Imaging 2008;28:390–395. © 2008 Wiley‐Liss, Inc.