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Conspicuity of zones of ablation after radiofrequency ablation in porcine livers: Comparison of an extracellular and an SPIO contrast agent
Author(s) -
Bangard Christopher,
Stippel Dirk L.,
Berg Frank,
Kasper Hans U.,
Hellmich Martin,
Fischer Jürgen H.,
Hölscher Arnulf,
Lackner Klaus,
Gossmann Axel
Publication year - 2008
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.21423
Subject(s) - medicine , nuclear medicine , magnetic resonance imaging , gadolinium , contrast to noise ratio , lesion , radiofrequency ablation , ablation , meglumine , radiology , pathology , image quality , chemistry , organic chemistry , artificial intelligence , computer science , image (mathematics)
Purpose To compare conspicuity of zones of ablation on nonenhanced, gadopentetate dimeglumine‐(Gd‐DTPA) and ferucarbotran‐(SPIO)‐enhanced magnetic resonance (MR) images. Materials and Methods In all, 33 radiofrequency ablations (RFA) were performed in 17 healthy porcine livers at 1.5T MR imaging 1 day and 2 and 4 weeks after RFA: T2‐weighted (w) ultra turbo spin echo (UTSE), proton density (PD)‐w UTSE, T1‐w gradient echo (GRE) pre‐ and 5 minutes postcontrast administration, dynamic T1‐w GRE during Gd‐DTPA (Magnevist) or SPIO (Resovist) administration, T2‐w UTSE, and PD‐w UTSE sequences 10 minutes after SPIO administration. Regions of interest (ROIs) for contrast‐to‐noise ratio (CNR) and signal‐to‐noise ratio (SNR) were drawn in consensus by two radiologists. Results PD‐w SPIO‐enhanced images (23.5 ± 5.5) showed higher liver‐to‐lesion CNR than T1‐w GRE Gd‐DTPA‐enhanced images (13.5 ± 6.1) 1 day after RFA ( P ≤ 0.05). At all other timepoints, liver‐to‐lesion CNR of PD‐w and T2‐w SPIO‐enhanced images did not differ significantly from T1‐w GRE Gd‐DTPA‐enhanced images ( P ≥ 0.05). Nonenhanced T2‐w images revealed lower liver‐to‐lesion CNR (7.0 ± 7.5/6.5 ± 5.9/6.8 ± 5.0, 1 day/2 weeks/4 weeks, respectively) than T2‐w SPIO‐enhanced (17.4 ± 4.8/15.3 ± 4.5/14.2 ± 5.7), PD‐w SPIO‐enhanced (23.5 ± 5.5/16.9 ± 3.6, 1 day/2 weeks), and T1‐w Gd‐DTPA‐enhanced (15.3 ± 3.6/12.7 ± 3.5, 2/4 weeks) images ( P ≤ 0.05). Liver‐to‐lesion CNR of SPIO‐enhanced dynamic T1‐w GRE images after 30, 80, 150, and 240 seconds did not change significantly over time ( P ≥ 0.05). Conclusion One day after RFA lesion conspicuity on PD‐w ferucarbotran‐enhanced images is better than on T1‐w GRE Gd‐DTPA‐enhanced images. At all other timepoints, ferucarbotran is not superior to gadolinium. Ferucarbotran‐ and gadolinium‐enhanced images improve lesion conspicuity compared with nonenhanced T2‐w images at all timepoints. J. Magn. Reson. Imaging 2008;28:263–270. © 2008 Wiley‐Liss, Inc.