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Multicompartmental analysis of late contrast enhancement in areas of myocardial infarction supplied by chronically occluded coronary arteries
Author(s) -
Mandry Damien,
Lapicque Françoise,
Odille Freddy,
Djaballah Wassila,
Codreanu Andrei,
Escanyé JeanMarie,
Felblinger Jacques,
Karcher Gilles,
Claudon Michel,
Marie PierreYves
Publication year - 2009
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.21382
Subject(s) - coronary arteries , myocardial infarction , medicine , cardiology , infarction , contrast (vision) , gadolinium , artery , chemistry , physics , organic chemistry , optics
Purpose To analyze the relationship between late contrast enhancement (LCE) and the interstitial distribution volume (V In ) of gadolinium (Gd) tracers in the myocardial infarction (MI) areas supplied by chronically occluded arteries from patients. In animal experimental models, LCE has already been shown to correspond to an enhanced V In of Gd tracers and thus, to a decrease in the amount of intact cells. Materials and Methods A multicompartmental analysis was applied to serial MRI images encompassing both infarct and remote areas and recorded with a conventional two‐dimensional (2D) segmented inversion‐recovery gradient‐echo (IR‐GRE) sequence during a 15‐minute period following Gd‐diethylenetriamine pentaacetic acid (Gd‐DTPA) injection in 12 patients with Q‐wave MI supplied by chronically occluded coronary arteries. Results V In from infarct tissue was: 1) higher than V In from remote areas (in % of myocardial volume: 74 ± 16% vs. 20 ± 7%, P < 0.001); and 2) correlated with the quantification of LCE between infarct and noninfarct areas at the 15th minute (R 2 = 0.63, P = 0.002). However, the difference in V In between infarct and remote myocardium was a much better correlate of this quantified LCE (R 2 = 0.85, P < 0.001). Conclusion Detection of LCE in the MI territories supplied by chronically occluded arteries relates to the difference in the V In of tracers between the infarct and the noninfarct areas. J. Magn. Reson. Imaging 2009;29:78–85. © 2008 Wiley‐Liss, Inc.