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3D dynamic contrast‐enhanced MRI of rectal carcinoma at 3T: Correlation with microvascular density and vascular endothelial growth factor markers of tumor angiogenesis
Author(s) -
Zhang Xiao Ming,
Yu Dexin,
Zhang Hong Lei,
Dai Yong,
Bi Dongsong,
Liu Zhiyan,
Prince Martin R.,
Li Chuanfu
Publication year - 2008
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.21378
Subject(s) - medicine , angiogenesis , vascular endothelial growth factor , immunohistochemistry , rectal carcinoma , carcinoma , dynamic contrast , dynamic contrast enhanced mri , pathology , adenocarcinoma , colorectal cancer , nuclear medicine , vegf receptors , urology , magnetic resonance imaging , cancer , radiology
Purpose To determine how dynamic contrast‐enhanced (DCE) MRI at 3T correlates with rectal carcinoma angiogenesis. Materials and Methods Three‐dimensional (3D) DCE MRI was performed in 38 patients (23 males, 15 females, mean age 60 years) with histologically‐confirmed rectal carcinoma at 3T. Time‐intensity curves (TICs) were used to measure peak enhancement ratio (ER peak ), time to peak enhancement (T peak ), first enhancement time (T first‐enhance ), and uptake rate for rectal tumor, normal rectal wall, and gluteal muscle. After tumor resection, microvascular density (MVD) and vascular endothelial growth factor (VEGF) expression were determined using immunohistochemistry (IHC) stains on available specimens ( N = 24) to correlate with DCE MRI. Results Rectal carcinoma showed higher ER peak (3.0 ± 0.9 vs. 1.9 ± 0.9, P < 0.001), higher uptake rate (2.8 ± 1.5/minute vs. 1.2 ± 0.9/minute, P < 0.001), earlier T peak (88 ± 56 seconds vs. 124 ± 72 seconds, P = 0.027), and earlier T first‐enhance (34 ± 6 seconds vs. 40 ± 7 seconds, P = 0.008) than normal rectal wall. Adenocarcinoma had shorter T peak compared to signet cell carcinoma (77 ± 48 seconds vs. 160 ± 62 seconds, P = 0.004). T peak was negatively correlated with MVD (r = –0.516, P = 0.01) and the mean T peak was significantly earlier for the VEGF‐positive group compared to the VEGF‐negative group (57 ± 17 seconds vs. 107 ± 64 seconds, P = 0.021). Conclusion DCE MRI parameters help predict rectal tumor angiogenesis measured by MVD and VEGF expression and discriminate malignant from normal tissue. J. Magn. Reson. Imaging 2008;27:1309–1316. © 2008 Wiley‐Liss, Inc.