Premium
High temporal resolution functional MRI using parallel echo volumar imaging
Author(s) -
Rabrait Cécile,
Ciuciu Philippe,
Ribés Alejandro,
Poupon Cyril,
Le Roux Patrick,
DehaineLambertz Ghislaine,
Le Bihan D.,
Lethimonnier F.
Publication year - 2008
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.21329
Subject(s) - computer science , temporal resolution , functional imaging , tikhonov regularization , functional magnetic resonance imaging , magnetoencephalography , artificial intelligence , real time mri , neuroimaging , echo time , pattern recognition (psychology) , magnetic resonance imaging , physics , neuroscience , inverse problem , mathematics , medicine , radiology , psychology , electroencephalography , mathematical analysis , quantum mechanics
Purpose To combine parallel imaging with 3D single‐shot acquisition (echo volumar imaging, EVI) in order to acquire high temporal resolution volumar functional MRI (fMRI) data. Materials and Methods An improved EVI sequence was associated with parallel acquisition and field of view reduction in order to acquire a large brain volume in 200 msec. Temporal stability and functional sensitivity were increased through optimization of all imaging parameters and Tikhonov regularization of parallel reconstruction. Two human volunteers were scanned with parallel EVI in a 1.5T whole‐body MR system, while submitted to a slow event‐related auditory paradigm. Results Thanks to parallel acquisition, the EVI volumes display a low level of geometric distortions and signal losses. After removal of low‐frequency drifts and physiological artifacts, activations were detected in the temporal lobes of both volunteers and voxelwise hemodynamic response functions (HRF) could be computed. On these HRF different habituation behaviors in response to sentence repetition could be identified. Conclusion This work demonstrates the feasibility of high temporal resolution 3D fMRI with parallel EVI. Combined with advanced estimation tools, this acquisition method should prove useful to measure neural activity timing differences or study the nonlinearities and nonstationarities of the BOLD response. J. Magn. Reson. Imaging 2008;27:744–753. © 2008 Wiley‐Liss, Inc.