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Quantification of MRI measured myocardial perfusion reserve in healthy humans: A comparison with positron emission tomography
Author(s) -
FritzHansen Thomas,
Hove Jens D.,
Kofoed Klaus F.,
Kelbaek Henning,
Larsson Henrik B.W.
Publication year - 2008
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.21306
Subject(s) - perfusion , medicine , positron emission tomography , nuclear medicine , dipyridamole , perfusion scanning , myocardial perfusion imaging , cardiology
Abstract Purpose To validate a noninvasive quantitative MRI technique, the K i perfusion method, for myocardial perfusion in humans using 13 N‐ammonia PET as a reference method. Materials and Methods Ten healthy males (64 ± 8 years) were examined with combined PET and MRI perfusion imaging at rest and during stress induced by dipyridamole in order to determine the myocardial perfusion reserve. Myocardial and blood time concentration curves obtained by Gd‐DTPA‐enhanced MRI and 13 N‐ammonia PET were fitted by a two‐compartment perfusion model. Results Mean perfusion values (±SD) derived from the MRI method at rest and at hyperemia were 80 ± 20 and 183 ± 56 mL/min/100 g, respectively. The same data for PET were 71 ± 16 and 203 ± 67 mL/min/100 g. A linear relationship was observed between MRI and PET‐derived myocardial perfusion reserve for regional and global data. Linear regression for the global absolute perfusion reserve gave a correlation coefficient of 0.96 ( P < 0.004, y=0.83x‐6.9). A good agreement between the two methods to determine low or high perfusion reserves was found. Conclusion Our data provide validation of the perfusion marker K i derived by the MRI method as a quantitative marker for myocardial perfusion in healthy humans. J. Magn. Reson. Imaging 2008;27:818–824. © 2008 Wiley‐Liss, Inc.