Premium
Assessment of tumor microcirculation with dynamic contrast‐enhanced MRI in patients with esophageal cancer: Initial experience
Author(s) -
Oberholzer Katja,
Pohlmann Andreas,
Schreiber Wolfgang,
Mildenberger Peter,
Kunz Peter,
Schmidberger Heinz,
Junginger Theodor,
Düber Cristoph
Publication year - 2008
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.21305
Subject(s) - medicine , magnetic resonance imaging , microcirculation , esophageal cancer , dynamic contrast , dynamic contrast enhanced mri , basal cell , cancer , photodynamic therapy , radiology , chemistry , organic chemistry
Purpose To investigate the feasibility and impact of dynamic contrast‐enhanced magnetic resonance imaging (DCE‐MRI) on tumor characterization and response to radiochemotherapy (RCT) in patients with esophageal cancer. Materials and Methods A total of 48 patients underwent DCE‐MRI to assess tumor microcirculation based on a two‐compartment model function. Effects of RCT on kinetic parameters were studied in 12 patients with squamous cell carcinoma. Results Tumor microcirculation differs with respect to histological subtype: squamous cell carcinomas showed lower values of amplitude A (leakage space, P = 0.015) and higher contrast agent exchange rates (k 21 , P = 0.225) compared with adenocarcinomas. RCT led to a significant decrease of the contrast agent exchange rate ( P = 0.005), while amplitude A increased moderately after therapy ( P = 0.136). Conclusion DCE‐MRI is feasible in patients with esophageal cancer, reveals therapeutic effects, and may thus be useful in therapy management and monitoring. J. Magn. Reson. Imaging 2008;27:1296–1301. © 2008 Wiley‐Liss, Inc.