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A fast navigator‐gated 3D sequence for delayed enhancement MRI of the myocardium: Comparison with breathhold 2D imaging
Author(s) -
Nguyen Thanh D.,
Spincemaille Pascal,
Weinsaft Jonathan W.,
Ho Bernard Y.,
Cham Matthew D.,
Prince Martin R.,
Wang Yi
Publication year - 2008
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.21296
Subject(s) - medicine , nuclear medicine , magnetic resonance imaging , image quality , confidence interval , contrast to noise ratio , radiology , artificial intelligence , computer science , image (mathematics)
Purpose To develop a rapid navigator‐gated three‐dimensional (3DNAV) delayed‐enhancement MRI (DE‐MRI) sequence for myocardial viability assessment, and to evaluate its performance with breathhold two‐dimensional (2DBH) DE‐MRI sequence as the reference standard. Materials and Methods 2DBH DE‐MRI was initiated 10 minutes after contrast administration and followed by 3DNAV DE‐MRI in 23 patients at 1.5 T. Comparison was performed using three qualitative criteria (image quality score, diagnostic outcome, relative diagnostic confidence score) in all patients, and three quantitative criteria (infarct volume, infarct signal‐to‐noise ratio [SNR inf ], and infarct‐viable myocardium contrast‐to‐noise ratio [CNR inf‐myo ]) in patients with hyperenhanced myocardium. Results Compared to 2DBH DE‐MRI, 3DNAV DE‐MRI provided slightly better image quality, the same final diagnostic outcomes, and better relative diagnostic confidence score with 79% SNR inf improvement ( P = 0.002) and 90% CNR inf‐myo improvement ( P = 0.004) in 39% less scan time (414 ± 118 seconds for 2DBH and 251 ± 93 seconds for 3DNAV). The measured infarct volumes demonstrated excellent correlation (18.9 ± 19.0 mL for 2DBH DE‐MRI vs. 17.6 ± 19.0 mL for 3DNAV DE‐MRI, r 2 = 0.998, P < 0.001, N = 7) and narrow limits of agreement (–1.3 ± 1.8 mL). Conclusion 3DNAV DE‐MRI provides improved image quality and similar infarct detection in less scan time compared to the standard 2DBH DE‐MRI. J. Magn. Reson. Imaging 2008. © 2008 Wiley‐Liss, Inc.